The gene UPF1 (up-frameshift suppressor 1 homolog) is mapped to human chromosome 19p13.11. It belongs to the helicase superfamily 1. The protein localizes in the cytoplasm.
Synonyms: Anti-ATP-dependent helicase RENT1; Anti-NORF1; Anti-Nonsense mRNA reducing factor 1; Anti-Regulator of nonsense transcripts 1; Anti-Up-frameshift suppressor 1 homolog; Anti-hUpf1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: UPF1 (up-frameshift suppressor 1 homolog) regulates nonsense-mediated mRNA decay pathway and translation termination. It plays crucial role in degradation of histone mRNAs. Mutations in UPF1 are associated with pancreatic adenosquamous carcinoma.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC