UPF1 (UPF1 regulator of nonsense transcripts homolog, yeast) is an ATP-dependent RNA helicase and phosphoprotein associated with several biological processes.
Synonyms: UPF1 Antibody - Anti-UPF1 antibody produced in rabbit; Upf1 Antibody; Anti-ATP-dependent helicase RENT1; Anti-NORF1; Anti-Nonsense mRNA reducing factor 1; Anti-Regulator of nonsense transcripts 1; Anti-Up-frameshift suppressor 1 homolog; Anti-hUpf1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: UPF1 (UPF1 regulator of nonsense transcripts homolog, yeast) is mainly involved in nonsense-mediated mRNA decay (NMD) of mRNA. During the protein-mediated interaction, eukaryotic initiation factor 3 (eIF3) can directly bind to UPF1 without depending on the UPF1's phosphorylation state. Once accumulated in mRNA, it gets phosphorylated prior to the transportation in the cytoplasm as part of the mRNP. UPF1 also plays an important role in the Staufen1-mediated mRNA decay (SMD). Both the paralogues of STAU, STAU1, and STAU2 directly interact with UPF1 and form homodimers and heterodimers to mediate SMD.
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