Uromodulin (UMOD) is a glycoprotein produced particularly in renal tubular cells and released into urine. The gene is located on human chromosome 16p12.3. It is the most abundant protein in urine.
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Uromodulin (UMOD) plays an important role in inflammatory responses and acts as a potential therapeutic for hypertension. It provides innate immunity and protects from kidney stones. The protein provides protection from uropathogenic bacteria. Mutations in this gene is associated with inflammation and development of kidney diseases, such as medullary cystic kidney disease 2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) and familial juvenile hyperuricemic nephropathy (FJHN).
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