The ubiquitin C-terminal hydrolase L1 (UCH-L1) gene is mapped to human chromosome 4p13. The protein localized in the cytosol and nucleus. UCH-L1 protein is primarily expressed in neuroendocrine tissues, neurons and in testis/ovary. Rabbit polyclonal anti-UCHL1 antibody recognizes ubiquitin carboxyl-terminal hydrolase isozyme L1.
Synonyms: UCHL1 Antibody - Anti-UCHL1 antibody produced in rabbit; Uchl1 Antibody; Anti-Neuron cytoplasmic protein 95; Anti-PGP 95; Anti-PGP9.5; Anti-UCH-L1; Anti-Ubiquitin carboxyl-terminal hydrolase isozyme L1; Anti-Ubiquitin thioesterase L1
Storage: -20C
Application: Anti-UCHL1 antibody produced in rabbit has been used in:
• immunohistochemistry at 1:100 dilution
• immunofluorescence
• proximity ligation assay
• indirect immunolabeling at 1:1000 dilution
Biochem Physiol Actions: Ubiquitin C-terminal hydrolase-L1 (UCHL1) is a deubiquitinating enzyme (DUB) that hydrolyzes C-terminal ubiquitin esters and amides, and peptide-ubiquitin amides to ubiquitin monomers in- vitro. In addition to DUB activity, it also possesses E3 ubiquitin-protein ligase activity. UCHL1 is involved in the regulation of the ubiquitin-dependent proteolytic system. UCH-L1 plays a vital role in cancer development and progression by upstream activation of protein kinase B (Akt). Mutation in the UCHL1 gene is associated with the development of Parkinson's disease (PD).
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