The ubiquitin protein ligase E3A (UBE3A) gene is mapped to human chromosome 15q11-q13. UBE3A codes for E6-AP ubiquitin-protein ligase, which belongs to E3 ubiquitin ligase protein family. The members of this family consist of a homologous to E6AP C-terminus (HECT) domain involved in the transfer of ubiquitin from E2 to the substrate.
Synonyms: Anti-ANCR; Anti-AS; Anti-E6-AP; Anti-EPVE6AP; Anti-FLJ26981; Anti-HPVE6A; Anti-Ubiquitin protein ligase E3A
MDL Number: MFCD03456070
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: The ubiquitin protein ligase E3A (UBE3A) functions as an E3 ligase in the ubiquitin-proteasome pathway and acts as a transcriptional co-activator of steroid hormone receptors such as progesterone and estrogen. During papillomavirus infection, ubiquitin protein ligase E3A (UBE3A), along with E6 viral protein, plays a vital role in degradation of the cell cycle regulatory protein p53. Anomalistic degradation of p53 can cause cervical cancer. Inactivation or deletion of UBE3A gene leads to the neurodevelopmental disorder Angelman syndrome (AS), while overexpression of maternal UBE3A gene is associated with autism pathogenesis. Therefore, UBE3A level has to be properly controlled for normal brain development.
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