Anti-Tubulin, Tyrosine antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the TUB-1A2 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse. Tubulin is an intracellular cylindrical filamentous structure and is presented in eukaryotic cells. It consists of three isoforms a-, ß- and ?-tubulin. Tubulin is a heterodimer of a- and ß- tubulin subunits.
Synonyms: Tubulin Alpha-1 Chain
Storage: -20C
Application: Anti-Tubulin, Tyrosine antibody, mouse monoclonal may be used in:
•immunoblotting
•immunofluorescence
•immunohistochemistry
Biochem Physiol Actions: Tubulin is the major building block of microtubules which is essential for structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton. It is also involved in the nervous system. Tubulin is associated with neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Mutations in the aß- dimers and ?-tubulin are associated with malformation and impairment of cognitive disorders.