Anti-TTP (N-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyms: Anti-G0/G1 switch regulatory protein 24; Anti-GOS24; Anti-Growth factor-inducible nuclear protein NUP475; Anti-NUP475; Anti-RNF162A; Anti-TIS11; Anti-Tristetraprolin; Anti-Zfp36, Zinc finger protein 36 homolog Protein

Storage: -20C

UNSPSC Code: 12352203

General description: Tristetraprolin (TTP), also known as zinc-finger protein 36 (ZFP36), is a RNA-binding protein, encoded by the gene mapped to human chromosome 19q13.2. TTP is ubiquitously expressed and is characterized with a highly homologous RNA binding domain (RBD) with two CCCH zinc fingers (ZFs).

Application: TTP (N-terminal) antibody produced in rabbit has been used in following studies:. RNA EMSA supershift. immunoblotting. ribonucleoprotein immunoprecipitation (RNP-IP)

Biochem/physiol Actions: Tristetraprolin (TTP) plays a key role in maintaining the stability of certain adenosine/uridine AU-rich element (ARE) mRNAs, by removing of the poly(A) tail and enhancing mRNA turnover. The encoded protein participates in mRNA binding and destabilization.

Immunogen: synthetic peptide corresponding to amino acids 51-67 of human TTP, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.

Physical form: Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Target description: TTP (N-terminal) (also known as Tristetraproline, Zfp-36, TIS11A, and Growth factor-inducible nuclear protein NUP475) is an RNA-binding protein that suppresses inflammation by accelerating the degradation of cytokine mRNA. TTP belongs to a family of human