Synonyms: Anti-ESCRT-I complex subunit TSG101; Anti-Tumor susceptibility gene 101 protein
MDL Number: MFCD08705528
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem Physiol Actions: Tumor susceptibility gene 101 is a human gene that encodes for a cellular protein. It is involed in infection of various papillomaviruses (PVs), and is also responsible for the trafficking of human papillomaviruses (HPV) through the ESCRT machinery and multi-vesicular bodies (MVBs), which forms a part of virus entry. The expression of this gene is related with the TNM stage and metastasis of HCC (hepatocellular carcinoma). It is also found to be expressed in breast cancer cells. Inactivation of this gene in breast cancer cells results in apoptosis and prevents proliferation. The gene might be involved in the control of the MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinases) signaling pathway in breast cancer.
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