Transient receptor potential cation channel subfamily V member 4 is a multitransmembrane non-selective cation channel encoded by the TRPV4 (also known as CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VR-OAC, VRL-2, VRL2, VROAC) gene and belong to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the transient receptor potential (TRP)3 superfamily of channels. Ankyrin (ANK) repeats/domains are shown to be important for functional channel expression, and ANK domain mutations are found in patients suffering from Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and hereditary motor and sensory neuropathies (HMSN). (PMID 16293632, 20037587, 20037588).
Synonyms: Trpv4, Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid recep
Application: Research Sub CategorySignaling Neuroscience
Other Notes: Concentration: Please refer to lot specific datasheet.