Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone H3 variants (H3.1, H3.2 and H3.3) have been implicated in the epigenetic memory of cellular state. Genome-wide patterns of H3 are dependent on amino acid sequence and change with cellular differentiation at developmentally regulated loci.
Synonyms: Histone H3.1t, H3/t, H3t, H3/g, trimethyl-Histone (Lys27), Alexa Fluor 488 Conjugate
Application: This Anti-trimethyl-Histone H3 (Lys27) Antibody, Alexa Fluor(R) 488 Conjugate is validated for use in Immunocytochemistry for the detection of trimethyl-Histone H3.
Legal Information: ALEXA FLUOR is a registered trademark of Life Technologies
Other Notes: Concentration: Please refer to lot specific datasheet.