TREML1 (Triggering receptor expressed on myeloid cells-like 1) is a platelet immunoreceptor membrane protein belonging to the TREM family. It consists of a single Ig superfamily V-type domain and a cytoplasmic tail with two immunoreceptor tyrosine-based inhibition motifs (ITIMs) for inhibitory functions. It is expressed in platelets and alpha-granules of megakaryocytes.
Synonyms: Anti-TLT-1; Anti-Trem-like transcript 1 protein precursor; Anti-Triggering receptor expressed on myeloid cells-like protein 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: TREML1 (Triggering receptor expressed on myeloid cells-like 1) is majorly involved in the platelet aggregation. It binds to the fibrinogen directly, thereby contributing to the inflammatory responses. It shows inhibitory actions in calcium signaling pathway by recruiting Src homology 2 domain-containing tyrosine phosphatase (SHP)2. Activated soluble TREML1 migrates to the platelet surface during inflammation. It has been suggested that migration of TREML1 may play an important role in vascular hemostasis. Furthermore it accelerates the rate of actin polymerization, platelet aggregation, and adherence to the endothelium during homostasis.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC