Anti-Trem2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Synonyms: Anti-Trem2a; Anti-Trem2b; Anti-Trem2c; triggering receptor expressed on myeloid cells 2

Storage: -20C

UNSPSC Code: 12352203

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General description: TREM2 (triggering receptor expressed on myeloid cells 2) is a transmembrane receptor belonging to the immunoglobulin (Ig) family. It is composed of an extracellular region containing the Ig-like domain and a cytoplasmic tail. It has a transmembrane region of 33 amino acids followed by a cytoplasmic tail. It is expressed on myeloid cells such as, macrophages found in tissue and dendritic cells, on microglial cells in the brain.

Application: Anti-Trem2 antibody produced in goat is suitable for indirect ELISA and western blot assays.

Biochem/physiol Actions: TREM2 (triggering receptor expressed on myeloid cells 2) is involved in the bacterial phagocytosis and regulation of inflammatory response. Its presence in microglia helps to remove the neural debris i.e. amyloid β peptide (Aβ) on microglia. TREM2 suppresses the ability of microglia to phagocytize Aβ, and disturbs the pro-inflammatory activity of these cells. Parkinson′s disease (PD) is portrayed by the degeneration of dopaminergic neurons, in the substantia nigra standards compacta district of the cerebrum. TREM2 binds specifically to the ligands expressed by these dopaminergic neurons. Likewise, microgliosis is additionally involved in the movement of PD. Hence, several type of TREM2 gene might be linked to susceptibility to PD. p.R47H polymorphism in this gene is identified with increased risk of sporadic amyotrophic sidelong sclerosis. Mutation in TREM2 is also associated with polycystic lipomembranous osteodysplaysia with sclerosing leukoencephalop.

Immunogen: Peptide with sequence CQVEHSTSRNQET, from the internal region of the protein sequence according to NP_112544.1.

Physical form: Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.