Topoisomerase IIß (TOP2B) is an isoform of type IIA topoisomerases. It is expressed in mammalian cells. This nuclear enzyme is mainly found in the neurons. The TOP2B gene is located on human chromosome location 3p24.2.
Synonyms: Anti-DNA topoisomerase 2-beta; Anti-DNA topoisomerase II, beta isozyme
Storage: -20C
Application: Anti-TOP2B antibody produced in rabbit has been used in western blotting and immunofluorescence staining.
Biochem Physiol Actions: Topoisomerase IIß (TOP2B) is vital for resolving topological problems of DNA, which is associated with gene regulation in neurons. It is also crucial for neuron development. Top2b modulates neuronal differentiation in vivo and in vitro. It is also vital for the development of cerebellum. Top2b is implicated in chromatid separation, chromosome condensation and the relief of torsional stress, which happens due to DNA transcription and replication. Reduced activity of Top2b is associated with ataxia-telangiectasia.
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