Synonyms: Anti-DNA topoisomerase I, mitochondrial precursor antibody produced in rabbit; Anti-TOP1mt antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: TOP1MT (topoisomerase (DNA) I, mitochondrial) encodes a type IB topoisomerase. At the N-terminal end, it contains a mitochondrial localization sequence instead of a nuclear localization signal, thus, called as TOP1MT. In presence of divalent metal (Ca2+ or Mg2+) and alkaline pH, it shows optimum activity in several DNA metabolic processes. It is essentially required for DNA strand entanglements, chromatin compaction, and DNA decatenation during replication and recombination.
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