TOM1L2 (target of myb1 like 2 membrane trafficking) is a widely expressed gene mapped to human chromosome 17p11.2. The protein has a VHS (Vps27p/Hrs/Stam) domain and a GAT (GGA and Tom1) domain. It belongs to the TOM1 (target of myb1) family of proteins.
Synonyms: Anti-TOM1-like protein 2; Anti-Target of Myb-like protein 2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: TOM1L2 (target of myb1 like 2 membrane trafficking) is needed for bringing clathrin into endosomes. It also controls the formation of SFK (src family kinases) receptor complex and thereby negatively regulates the growth factor-mediated Src mitogenic signal transduction.
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