TMPO (thymopoietin) gene is mapped to human chromosome 12q22. Alternate splicing of the mRNA results in isoforms a (75kDa), ß (51kDa), and ? (39kDa), which are related nuclear proteins. The gene consists of eight exons spanning a length of ~35kb. Exon 4 is spliced into a mRNA, which encodes a putative basic nuclear localization motif. Exon 8 encodes a hydrophobic putative membrane-spanning domain that targets ß and ? isoforms to the nuclear membrane
Synonyms: Anti-Lamina-associated polypeptide 2, isoforms beta/gamma antibody produced in rabbit; Anti-TP beta/gamma antibody produced in rabbit; Anti-TPRP isoforms beta/gamma antibody produced in rabbit; Anti-Thymopoietin, isoforms beta/gamma antibody produced in rabbit; Anti-Thymopoietin-related peptide isoforms beta/gamma antibody produced in rabbit
MDL Number: MFCD02263594
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: TMPO (thymopoietin) gene is also called as LAP2 (Lamina-associated polypeptide 2) and functions in the assembly of the nuclear lamina. It is present in the nucleus and facilitates the maintenance of structural organization of the nuclear envelope. It serves as an anchor for the attachment of lamin filaments to the inner nuclear membrane.
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