Transmembrane protein 119 (TMEM119) is encoded by the gene mapped to human chromosome 12q23.3. The encoded protein belongs to the transmembrane protein family.
Synonyms: Tmem119 Antibody; Tmem119 Antibody - Anti-TMEM119 antibody produced in rabbit; Anti-transmembrane protein 119
Storage: -20C
Application: Anti-TMEM119 antibody produced in rabbit has been used in immunohistochemistry.
Biochem Physiol Actions: Transmembrane protein 119 (TMEM119) acts as an osteoinductive factor and facilitates proliferation, migration and invasion of osteosarcoma cells.(28} It is a critical molecule acting downstream of the parathyroid hormone (PTH) and similar to mothers against decapentaplegic-3 (Smad3) signaling pathways in osteoblasts. TMEM119 is considered to be a potential microglial marker that differentiates resident microglia from blood-derived macrophages in the human brain. Mutation in the gene is associated with the development of osteosarcoma.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC