Synonyms: Anti-TYH; tyrosine hydroxylase
Storage: -20C
UNSPSC Code: 12352203
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General description: Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. Tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla, and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
Biochem/physiol Actions: Tyrosine hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, which is involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson's disease (PD) and point mutation in the gene coding for TH leads to Segawa′s syndrome.
Immunogen: Peptide with sequence CVQDELDTLAHAL, from the C Terminus of the protein sequence according to NP_954986.2; NP_000351.2; NP_954987.2.
Physical form: Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
RIDADR: NONH for all modes of transport