Anti-TGFBR1 (center) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Synonyms: TGF-beta receptor type I, TGFR-1, TGF-beta type I receptor, Serine/threonine-protein kinase receptor R4, SKR4, Activin receptor-like kinase 5, ALK-5

Storage: -20C

UNSPSC Code: 12352203

General description: TGFBR1 (transforming growth factor β receptor 1) gene is mapped to human chromosome 9q22.33. TGFBR1 is known to localize in the focal adhesions of the cell surface.

General description: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

Application: Anti-TGFBR1 (center) antibody produced in rabbit has been used in western blot.

Biochem/physiol Actions: TGFBR1 (transforming growth factor β receptor 1) stimulates signaling pathway that mediates cell growth and division. The complex formed by TGFBR2 with TGFBR1 results in the phosphorylation and activation of TGFBR1. TGFBR1 is responsible for the activation of canonical Smad (mothers against decapentaplegic homolog 3) proteins and transcriptional factors Snail (zinc finger protein) and Twist (twist family bHLH transcription factor 1). The activation of a number of non-canonical effectors such as RhoA (ras homolog family member A), TAK1 (transforming growth factor-β-activated kinase 1) and Akt (RAC-α serine/threonine-protein kinase) is also associated with TGFBR1. The arrangement of the TGFBR1 receptor along with TGFBR2 at the focal adhesions mediates the multimerization and stimulation of TGFβ ligand. Downregulation of TGFBR1 is observed in breast cancer. TGFBR1 is also known to be associated with colorectal cancer.

Immunogen: TGFBR1 (NP_004603, 138-173)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1.

Physical form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.