TFB2M is a mitochondrial transcription factor that regulates the expression of SERCA2 gene in rat cardiomyocytes. It is also known to induce the transcription of human mtDNA.Rabbit Anti-TFB2M (AB1) antibody recognizes human and rat TFB2M.
Synonyms: Anti-FLJ22661; Anti-FLJ23182; Anti-Hkp1; Anti-Transcription factor B2, mitochondrial
Storage: -20C
Application: Rabbit Anti-TFB2M (AB1) antibody is suitable for western blot (1.25 mug/ml) and IHC (4-8 mug/ml) applications.
Biochem Physiol Actions: TFB2M is a S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. It is also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. It stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.