The gene TFAP2A (transcription factor AP-2-a) is mapped to human chromosome 6p24.3. It is a transcription factor. The protein has a helix-span-helix motif for DNA binding. TFAP2A protein can bind to G/C-rich elements. It belongs to the AP-2 transcription factor family of proteins.
Synonyms: Anti-AP-2; Anti-AP2TF; Anti-BLTR; Anti-CMKRL1; Anti-GPR16; Anti-LTB4R1; Anti-P2RY7; Anti-P2Y7; Anti-TFAP2; Anti-transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Storage: -20C
Application: All Prestige Antibodies(R)Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.Anti-TFAP2A antibody produced in rabbit has been used as a capturing agent for immunoenrichment coupled mass spectrometry.
Biochem Physiol Actions: TFAP2A (transcription factor AP-2-a) is involved in development, apoptosis and cell cycling, and oncogenesis. It is upregulated in presence of Hepatitis B virus X and is responsible for hepatoma cell growth. Changes in the expression of this gene are linked with various cancers, such as melanoma, prostate, breast, ovarian, gastric, colon and bladder cancers. TFAP2A controls expression of genes associated with proliferation (c-MYC), cell cycle (HER-2 (receptor tyrosine-protein kinase) and p21WAF1 (cyclin-dependent kinase inhibitor 1)), cell death (c-KIT (tyrosine-protein kinase), Bcl-2 (B-cell lymphoma 2), and FAS (tumor necrosis factor receptor superfamily member)), cell attachment (MUC18 (melanoma-associated antigen) and E-cadherin), and tumor invasion/angiogenesis (MMP-9 (matrix metalloproteinase), PAI-I (plasminogen activator inhibitor), and PAR-1 (protease-activated receptor)). Mutations in this gene are associated with branchio-oculo-facial syndrome.
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