Synonyms: Anti-AI661103; Anti-Hmgts; Anti-MtTFA; Anti-Transcription factor A, mitochondrial; Anti-TsHMG
Storage: -20C
Biochem Physiol Actions: TFAM a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this protein is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns Sayre syndrome was produced when expression of the gene was eliminated by targeted disruption in heart and muscle cells.