TCF-4 belongs to the Tcf family of transcription factors that activate genes induced by the Wnt pathway.
Synonyms: Anti-E2-2; Anti-ITF2; Anti-SEF2; Anti-SEF2-1; Anti-SEF2-1A; Anti-SEF2-1B; Anti-Transcription factor 4
Storage: -20C
Application: Anti-TCF4 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 0.25 mug/ml.
Biochem Physiol Actions: TCF-4 mediates the transformation of epithelial cells of colon in the absence of APC gene expression. The expression of TCF-4 is required to establish the proliferative progenitors to form the crypts of embryonic small intestine. TCF-4 collaborates with ß-catenin to regulate the colorectal transformation process. Lack of TCF-4 expression results in developmental delay and intellectual disability termed as Pitt-Hopkins syndrome.