The gene TBL1XR1 (transducin ß-like 1X-related protein 1) is mapped to human chromosome 3q26.32. The protein contains four WD40 (ß-transducin) repeats. TBL1XR1 is also referred as TBLR1 (TBL1-related protein 1).
Synonyms: Anti-F-box-like/WD repeat-containing protein TBL1XR1; Anti-Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; Anti-TBL1-related protein 1; Anti-Transducin beta-like 1X-related protein 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: TBL1XR1 (transducin ß-like 1X-related protein 1) regulates the change from gene repression to activation of nuclear receptors and proteins involved in transcriptional activation. It also functions as an E3-ligase. TBL1XR1 haploinsufficiency results in intellectual disability, without autistic behavior. Mutations in TBL1XR1 are linked with autism spectrum disorders. TBL1XR1 is involved in progression of breast cancer cells by transactivation of cyclin D1 and activation of the ß-catenin signaling pathway.
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