Contactin-2 (UniProt P22063; also known as Axonal glycoprotein TAG-1, Axonin-1, Transient axonal glycoprotein 1, TAX-1) is encoded by the Cntn2 (also known as Tax1) gene (Gene ID 25356) in rat species. Proper localization of the voltage-gated Na+ channels to the node of Ranvier and voltage-gated K+ channels to the juxtaparanode (JXP) along myelinated axons is essential for the fast propagation of action potentials. Localization of clustered ion channels in specific membrane domains depends on specific cell adhesion molecules (CAMs), as well as on the integrity of neighboring domains. Contactin-2/TAG-1 and Caspr2 form a membrane scaffold complex that functions to cluster Kv1 potassium channels at the JXP. Deletion of either of these CAMs causes Kv1 channels to disappear from the JXP and to redistribute along the internode. Contactin-2/TAG-1 is initially produced with an N-terminal signal peptide (a.a. 1-30) and a C-terminal propeptide (a.a. 1016-1040) sequence, the removal of which yields the mature GPI-anchored membrane glycoprotein.
Synonyms: Contactin-2, TAG-1, Axonal glycoprotein TAG-1, Axonin-1, Transient axonal glycoprotein 1, TAX-1
Application: Research Sub CategoryDevelopmental Neuroscience
Other Notes: Concentration: Please refer to lot specific datasheet.