Spectrin repeat containing nuclear envelope protein 2 (SYNE2) was formerly known as nuclear envelope spectrin repeat protein (Nesprin-2), NUANCE and KASH (is an acronym for Klarsicht, ANC-1, Syne Homology) domain containing protein 2. The gene SYNE2 is localised on human chromosome on 14q23.2.
Synonyms: Anti-DKFZP434H2235; Anti-KIAA1011; Anti-NUA; Anti-NUANCE; Anti-Nesp2; Anti-Nesprin-2; Anti-SYNE-2
Storage: -20C
Application: Anti-SYNE2 antibody recognises SYNE2 protein.
Biochem Physiol Actions: Spectrin repeat containing nuclear envelope protein 2 (SYNE2) is involved in nuclear positioning in the multi-nucleated skeletal muscles in the early developmental stage. SYNE2 is a part of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is essential for connecting the nucleus to the cytoskeleton and other organelles. SYNE2 complexes with SUN2 of SUN proteins (Sad1 and UNC-84) and binds to F-actin to form transmembrane actin-associated nuclear (TAN) lines for actin-dependent nuclear movement. SYNE2 as a KASH domain protein, is involved in nuclear anchorage and migration. SYNE2 is essential for normal development of retina. Mutations in SYNE2 may cause retinal problems in photoreceptors, secondary neurons and muller glia. SYNE2 facilitates ciliogenesis in humans, which is necessary for numerous functions in the human including determining the left and right handedness.
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