Synonyms: Anti-AAPA3037; Anti-FGE; Anti-MGC131853; Anti-MGC150436; sulfatase modifying factor 1
Storage: -20C
UNSPSC Code: 12352203
Features and Benefits: Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description: Sulfatase modifying factor 1 (SUMF1) or formylglycine-generating enzyme (FGE) is a 41kDa glycoprotein. It is localized at the lumen of the endoplasmic reticulum. The protein consists of an amino-terminal domain and a core domain with the active site. The gene encoding SUMF1 is localized on human chromosome 3p26.1 and contains nine exons.
Biochem/physiol Actions: Sulfatase modifying factor 1 (SUMF1) converts a highly conserved cysteine in the catalytic domain of sulfatase to form C α-formylglycine (FGly) by post-translational modification. Mutations in the gene encoding this protein have been associated with multiple sulfatase deficiency.
Immunogen: Peptide with sequence CETLNPKGPPSGKDR, from the internal region of the protein sequence according to NP_877437.2.
Physical form: Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
RIDADR: NONH for all modes of transport