Synonyms: Anti-AP003355.2; Anti-Serine/threonine-protein kinase 3
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: STK3 (serine/threonine kinase 3) encodes a serine/threonine protein kinase. It is highly expressed in the adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. It is activated by trans-autophosphorylation at its activation loop. It is associated with the stress-dependent cardiac hypertrophy and remodeling in the human heart. It also suppresses the Wnt/ß-catenin pathway through the Hippo pathway. In association with other cytoplasmic protein kinase, STK3 regulates cellular activities during quiescence and quiescence-related apoptosis.
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