Signal transducers and activators of transcription 6 (STAT6) belongs to the family of DNA binding proteins. It is mainly involved with Interleukin-4 (IL-4)-mediated gene expression. Src homology-2 domain (SH2) domain of STAT6 binds to docking sites of IL-4 receptor a to get tyrosine-phosphorylated by the receptor-associated janus kinase (JAK). This binding activates SATAT6 and it forms homodimer. Further, it translocates to the nucleus for adhering with the high affinity STAT-binding elements (SBE) of IL-4/IL-13.
Synonyms: STAT Antibody - Anti-STAT6 antibody produced in rabbit; Stat6 Antibody; Anti-IL-4 Stat antibody produced in rabbit; Anti-Signal transducer and activator of transcription 6 antibody produced in rabbit
MDL Number: MFCD00803571
Storage: -20C
Application: These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC