The gene ST6GAL2 (ST6 ß-galactosamide a-2,6-sialyltranferase 2) belongs to the ST6Gal family that also includes another member, ST6Gal I. It is mainly expressed in embryonic and adult brain. It is also found to be expressed in small intestine and colon. The encoded protein is found to be 529 amino acids long and exhibits 48.9% amino acid sequence similarity with ST6Gal I. The ST6GAL2 gene is mapped to human chromosome 2q11.2-q12.1. It consists of eight exons spanning a length of 85kb. The protein contains type II transmembrane topology. All sialyltransferases of animal origin contain a short N-terminal tail that is cytoplasmic, a transmembrane domain, a stem region, and a catalytic domain with highly conserved motifs called sialylmotifs.
Synonyms: Anti-Alpha 2,6-ST 2; Anti-Beta-galactoside alpha-2,6-sialyltransferase 2; Anti-CMP-N- acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; Anti-ST6Gal II; Anti-ST6Gal-II; Anti-ST6GalII; Anti-Sialyltransferase 2; Anti-hST6Gal II
Storage: -20C
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Biochem Physiol Actions: The gene (ST6 ß-galactosamide a-2,6-sialyltranferase 2) encodes a putative sialyltransferase. It catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate having Galß1,4GlcNAc sequence at the nonreducing end of their carbohydrate groups through an a2, 6-linkage. It prefers the LacdiNAc structure as an acceptor substrate over the Galß1-4GlcNAc structure.
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