SSR3 (signal sequence receptor, gamma) is also called TRAP (translocon-associated protein)?, and forms a subunit of the TRAP complex, which also includes a, ß and d subunits. This subunit has a molecular weight of 20kDa. This complex is present in ER (endoplasmic membrane) membrane, and SSR3 has four membrane spanning domains. It interacts with the other subunits of TRAP complex, with its charged domain present between the first two and the last two transmembrane segments.
Synonyms: Anti-SSR-gamma; Anti-Signal sequence receptor subunit gamma; Anti-TRAP-gamma; Anti-Translocon-associated protein subunit gamma
Storage: -20C
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Biochem Physiol Actions: SSR3 (signal sequence receptor, ?) is a subunit of TRAP (translocon-associated protein) complex, which is responsible for translocation of membrane proteins from the ER (endoplasmic reticulum) to the plasma membrane. It is thought to be a functional part of the translocon, and interacts with Sec61 to form a heterotetramer. It also regulates the post-translational modifications of the translocating proteins. The TRAP complex might also play a role in the unfolded protein response (UPR) pathway. Studies in mice show that SSR3 is essential for the formation of vascular network in mice palcenta. It is an interacting partner of the orphan nuclear receptor TR3, and interacts through its C-terminal with the ligand-binding domain of TR3. This interaction mediates ER-stress, as well as induces apoptosis.
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