Spectrin ß chain, non-erythrocytic 1 (SPTBN1) is expressed in the brain, lungs and kidneys. The gene encoding it is present on chromosome 2p21 and consists of 32 exons encoding an actin-binding domain, 17-spectrin repeats, and a short COOH-terminal which has regulatory function.
Synonyms: Anti-Beta-II spectrin; Anti-Fodrin beta chain; Anti-Spectrin beta chain, brain 1; Anti-Spectrin, non-erythroid beta chain 1
Storage: -20C
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Biochem Physiol Actions: Spectrin ß chain, non-erythrocytic 1 (SPTBN1) may take part in assembling the specialized plasma membrane region of Purkinje neurons. The interaction of the carboxy-terminal domain of schwannomin and the ankyrin-binding region of SPTBN1 helps it to play an important role in actin-cytoskeleton organization. SPTBN1 also binds to protein receptors on the plasma membrane without the help of ankyrin and is essential for the normal formation of nervous and cardiac tissue.
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