The gene SPEG (striated muscle preferentially expressed protein kinase) is mapped to human chromosome 2q35. It belongs to myosin light chain kinases (MLCK) family of signaling proteins. SPEG is a striated muscle protein and is present to the sarcoplasmic reticulum region in myofibers.
Synonyms: Anti-APEG-1; Anti-Aortic preferentially expressed protein 1; Anti-Striated muscle preferentially expressed protein kinase
Storage: -20C
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Biochem Physiol Actions: Striated muscle preferentially expressed protein kinase (SPEG) interacts with lipid phosphatase myotubularin (MTM1). Mutations in SPEG are associated with centronuclear myopathies phenotype and cardiomyopathy. In rat model, SPEG transcripts level decreases in presence of vascular injury and SPEG was suggested to be involved in growth and differentiation of arterial smooth muscle cell types.
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