Sperm adhesion molecule 1 (SPAM1) belongs to the hyaluronidase family and the gene encoding it is localized on human chromosome 7q31.
Synonyms: Anti-Hyal-PH20; Anti-Hyaluronidase PH-20 precursor; Anti-Hyaluronoglucosaminidase PH-20; Anti-Sperm adhesion molecule 1; Anti-Sperm surface protein PH-20
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Sperm adhesion molecule 1 (SPAM1) is involved in the depolymerisation of hyaluronan into fragments of varying sizes. It breaks the hexosaminidic linkages between N-acetyl-D-glucosamine and D-glucuronic acid residues of hyaluronan thus giving rise to oligosaccharides or larger polymers. A down regulation of the SPAM1 gene may be associated with endometrial carcinomas.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC