SMC3 codes for a part of the cohesion complex that regulates chromosome segregation during mitosis. It is known to form a heterodimer with SMC1, which subsequently can restructure the double helical form of DNA into a series of loops. Studies have reported that the opening of the Smc3-Scc1 gate is needed for removal of cohesion from chromosomes during prophase. However, in Drosophila, the disengagement of Smc3/kleisin interface releases cohesin from chromosomes during mitosis and interphase.Rabbit Anti-SMC3 antibody recognizes human, mouse, rat, chicken, zebrafish, bovine, and canine SMC3.
Synonyms: Anti-BAM; Anti-BMH; Anti-CDLS3; Anti-CSPG6; Anti-HCAP; Anti-SMC3L1; Anti-Structural maintenance of chromosomes 3
Storage: -20C
Application: Rabbit Anti-SMC3 antibody is suitable for western blot applications at a concentration of 0.25mug/ml. The product can also be used for IHC applications.
Biochem Physiol Actions: SMC3 belongs to the SMC3 subfamily of SMC proteins. SMC3 occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation.