Organic solute transporter subunit ß (SLC51B) is a 128-amino acid, single-transmembrane domain containing polypeptide. It is localized in the small intestine, kidney and liver.
Synonyms: Anti-OSTBETA
Storage: -20C
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Biochem Physiol Actions: Organic solute transporter subunit ß (SLC51B) mediates the bile acid export and sterol reabsorption in the intestine. Along with OSTa, it forms a heteromeric transporter complex. The substrates of this transporter are bile acid taurocholate, steroid like digoxin and prostaglandin E2. Its expression is induced by the bile acids through ligand-dependent transactivation by the nuclear bile acid receptor/farnesoid X receptor (FXR).The transport function is Na+ independent and is inhibited by organic anions and steroids.
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