Synonyms: Anti-GLUT-8; Anti-Glucose transporter type 8; Anti-Glucose transporter type X1; Anti-Solute carrier family 2, facilitated glucose transporter member 8
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SLC2A8 (Solute carrier family 2, member 8) is a cell-surface localized, class III glucose and fructose transporter. It is involved in the glucose transport activity, hepatocyte fructose transport, and fructose-induced macrosteatosis. It is highly expressed in testis, brain, liver, heart, and other oxidative tissues. Its expression is also associated with the endosomes, lysosomes, and membranes of the endoplasmic reticulum. It facilitates the transport of glucose and its derivatives through intracellular membranes. It also mediates the translocation of fructose to its primary metabolism site i. e. hepatocytes. In testis, it provides fuel to mature spermatozoa for the sperm cell functioning. Alerations in SLC2A8 leads to non-alcoholic fatty liver disease (NAFLD).
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