Solute carrier family 12 member 1 (SLC12A1) belongs to the electroneutral cation-chloride cotransporter family. It possesses 12 transmembrane helices and the gene encoding it is localized on human chromosome 15.
Synonyms: Anti-Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Anti-Kidney-specific Na-K-Cl symporter; Anti-Solute carrier family 12 member 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Solute carrier family 12 member 1 (SLC12A1) takes part in the reabsorption of salt in the thick ascending loop of Henle. SLC12A1 transports one Na+, one K+ and two Cl- across the plasma membrane. It also regulates blood pressure. Mutations in the gene encoding this protein have been linked to type I Bartter syndrome.
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