Synonyms: Anti-Homeobox protein SIX6 antibody produced in rabbit; Anti-Homeodomain protein OPTX2 antibody produced in rabbit; Anti-Optic homeobox 2 antibody produced in rabbit; Anti-Sine oculis homeobox homolog 6 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SIX6 (Sine oculis homeobox homolog 6) gene encodes a homeobox protein that has similarity with the gene product of Drosophila 'sine oculis'. It is localized to chromosome 14 and may be involved in eye development. Missense mutations in this gene are linked with isolated microphthalmia with cataract type 2 (MCOPCT2). It has also been reported that SIX6 mutations cause optic disc anomalies and macular atrophy with reduced rate of retinal ganglion cell differentiation.
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