Sirtuin 3 (SIRT3) is a 399 amino acid protein, which belongs to the Sirtuins (SIRTs), a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases. Increased expression of SIRT3 is connected with extended lifespan of humans. SIRT3 gene is mapped to human chromosome 11p15.5. The protein is characterized with N-terminal mitochondrial targeting signal and a central catalytic domain. SIRT3 is expressed in several tissues including adipose tissue, brain and heart in both fetus and adults. It is also referred to as SIR2L3 (SIR2-like protein 3).
Synonyms: Anti-SIR2L3; Anti-sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
MDL Number: MFCD07784765
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Sirtuin 3 (SIRT3) plays a vital role in the regulation of enzymes involved in various cellular pathways, such as respiratory chain, ATP synthesis, ß-oxidation, tricarboxylic acid cycle and urea cycle, and decreases concentration of reactive oxygen species (ROS) and oxidative stress. SIRT3 is a novel gene involved in human ageing, therefore any abnormalities in the gene leads to several age-related diseases, such as cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. SIRT3 facilitates mitochondrial function and metabolism. Sirt3 modulates energy homeostasis via regulation of basal ATP levels.3 Inhibition of SIRT3 by LC-0296, might facilitate the development of new targeted therapies to treat patients with head and neck cancer.
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