Signal-induced proliferation-associated 1-like protein 1 is a novel E6-binding protein localized to chromosome 14q23.2-14q24.3 (within a locus, which undergoes loss of heterozygosity in malignant meningiomas). It possesses high homology with GTPase-activating proteins for Rap, including SPA-1, tuberin, and Rap1GAP.
Synonyms: Anti-E6-targeted protein 1 antibody produced in rabbit; Anti-High-risk human papilloma viruses E6 oncoproteins targeted protein 1 antibody produced in rabbit; Anti-Signal-induced proliferation-associated 1-like protein 1 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Signal-induced proliferation-associated 1-like protein 1 is a protein encoded by the SIPA1L1 gene in humans. There may be a potential link between HPV E6 oncogenesis and alteration of a small G protein signaling pathway. It plays an important role in malignant transformation and in the productive viral life cycle.
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