SIGLEC8 (Sialic acid binding Ig-like lectin 8) encodes a 54kDa type 1 transmembrane protein belonging to the immunoglobulin superfamily (IgSF). It consists of a transmembrane region, a V-set Ig like domain at the N-terminal end and a set of downstream C2-set domains. It is expressed in the eosinophilic granulocytes, mast cells, and basophills.
Synonyms: Anti-CD329 antigen; Anti-CDw329; Anti-SAF-2; Anti-Sialic acid-binding Ig-like lectin 8 precursor; Anti-Sialoadhesin family member 2; Anti-Siglec-8
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SIGLEC8 (Sialic acid binding Ig-like lectin 8) plays an important role in the eosinophil biology. It acts as an eosinophil-specific transmembrane receptor for sialic acid dependent binding. It has been reported that SIGLEC8 may be involved in the identification of and modulation of allergic cells.
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