Synonyms: Anti-alpha-SG antibody produced in rabbit; Anti-alpha-Sarcoglycan precursor antibody produced in rabbit; Anti-50 kDa dystrophin-associated glycoprotein antibody produced in rabbit; Anti-50DAG antibody produced in rabbit; Anti-Adhalin antibody produced in rabbit; Anti-Dystroglycan 2 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SGCA (sarcoglycan, a) gene encodes a 50kDa component of sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). The DGC forms a bridge between the F-actin cytoskeleton and the extracellular matrix and stabilizes the sarcolemma. The complex also protects the muscle fibers from long-term contraction-induced damage and necrosis. The DGC also contains dystrophin, a rod-shaped subsarcolemmal protein, with which the sarcoglycan subunits interacts. SGCA gene is mapped to human chromosome 17q21. Mutations in this gene may cause early onset autosomal recessive muscular dystrophy, especially limb-girdle muscular dystrophy, type 2D (LGMD2D).
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