Surfactant protein D (SFTPD) is expressed majorly by alveolar type II cells of the lung, epithelial surfaces, amniotic fluid and serum. The gene is located on human chromosome 10q22.3. It consists of an N-terminal domain with two conserved cysteines, a collagen-like region, an a helical neck region and a C-type lectin carbohydrate recognition domain (CRD).
Synonyms: Anti-COLEC7; Anti-SFTP4; Anti-SP-D
Storage: -20C
Application: Anti-SFTPD antibody produced in rabbit has been used in immunohistochemistry.
Biochem Physiol Actions: Surfactant protein D (SFTPD) plays an important role in innate immune system. It is linked to macrophage mediated inhibition of interleukin IL-12p40 via signal regulatory protein a (SIRPa)/ Rho-associated protein kinase (ROCK)/ extracellular signal regulated kinases (ERK) signalling pathway. The protein plays an anti-inflammatory role in lungs. SFTPD maintains surfactant homeostasis by regulating the structure of surfactant phospholipids.
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