Synonyms: Anti-EPC-1 antibody produced in rabbit; Anti-PEDF antibody produced in rabbit; Anti-Pigment epithelium-derived factor precursor antibody produced in rabbit; Anti-Serpin-F1 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein encoded by the SERPINF1 gene in humans. It is also referred as OI6, OI12, PEDF, EPC-1 and PIG35. It is more up-regulated in the involuting phase of hemangioma tissues than in the proliferating. It helps in accelerating the involution of hemangioma by growth inhibition of HemECs in an autocrine manner. It may act as a useful marker for evaluating the progression of diabetic nephropathy (DN). Homozygous mutations in this gene causes deficiency of pigment epithelium-derived factor (PEDF) and lead to osteogenesis imperfecta (OI) type VI.
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