SerPINE1 is a serine proteinase inhibitor that blocks fibrinolys by inhibiting tissue plasminogen activator (tPA) and urokinase (uPA). Genetic variations in SERPINE1 have been linked to pre-eclampsia (PE). Studies have reported that targeting SERPINE1 (PAI-1) expression in Alzheimer's disease may have therapeutic implications. Moreover, MiR-34c regulates SERPINE1 expression in emphysema.Rabbit Anti-SerPINE1 antibody recognizes human, mouse, rat, zebrafish, bovine, pig, chicken, and canine SERPINE1.
Synonyms: Anti-PAI; Anti-PAI-1; Anti-PAI1; Anti-PLANH1; Anti-Serpin peptidaSe inhibitor, clade E , member 1
MDL Number: MFCD00164749
Storage: -20C
Application: Rabbit Anti-SerPINE1 antibody is suitable for western blot applications at a concentration of 0.5 mug/ml.
Biochem Physiol Actions: SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.