SERPINA3 (serpin family A member 3) is a widely expressed protein that belongs to the serpin superfamily. It is synthesized by hepatocytes, bronchial epithelial cells and neuronal cells. It consists of a highly conserved fold and three ß-sheets along with ~8 a-helices. In addition to the a, ß region, it has a solvent-exposed stretch of amino acids called as the reactive center loop (RCL).
Synonyms: Anti-ACT; Anti-Alpha-1-antichymotrypsin precursor; Anti-Cell growth-inhibiting gene 24/25 protein
Storage: -20C
Application: Anti-SERPINA3 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SERPINA3 (serpin family A member 3) controls the release of leukocyte proteases during an inflammatory response. It has inhibiting nature for several proteases such as mast cell chymase, pancreatic chymotrypsin, human glandular kallikrein 2, kallikrein 3 (prostate-specific antigen), pancreatic cationic elastase and an uncharacterized lung serum protease. It inhibits the function of neutrophil cathepsin G, a pro-inflammatory enzyme and mast cell chymase, which is responsible for the conversion of angiotensin-1 to the active angiotensin-2. SERPINA3 also restricts inflammation, coagulation and extracellular matrix (ECM) remodeling. Overexpression of the protein is responsible for Alzheimer disease and cerebral amyloid encephalopathy. Deficiency of SERPINA3 causes lung and liver disease.
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