SEPT4 (septin4) belongs to the septin family of GTPases and the gene is mapped to human chromosome 17q23. It is expressed in liver, brain, and testes.
Synonyms: Anti-Bradeion beta; Anti-Brain protein H5; Anti-CE5B3 beta; Anti-Cell division control-related protein 2; Anti-Cerebral protein 7; Anti-Peanut-like protein 2; Anti-Septin-4; Anti-hCDCREL-2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SEPT4 (septin4) participates in cell apoptosis, cell cycle regulation and fibrogenesis. It is a Notch target gene. Changes in expression of SEPT4 might be associated with idiopathic asthenozoospermia. It is also responsible for TGF (transforming growth factor)-ß-mediated apoptosis.
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