Selenoprotein K (SELK) is an 11kDa protein and is expressed in the endoplasmic reticulum (ER).
Synonyms: Anti-SELK; Anti-AC012467.9; Anti-Selenoprotein K
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Selenoprotein K (SELK) functions in protecting hepatic (HepG2) cells from endoplasmic reticulum (ER) stress agent-induced apoptosis and is itself regulated by ER stress. It is a novel antioxidant in cardiomyocytes and is involved in the regulation of cellular redox balance. The protein SECIS binding protein 2 (SBP2) binds to the SELK Sec insertion sequence element (SECIS) through the conserved non-Watson-Crick base pair. SELK can regulate and determine the nature of the substrate translocated through the Derlin channel by interacting with the ER-associated degradation (ERAD) components like Derlins, p97 ATPase and selenoprotein S (SelS). Ca2+ influx during immune cell activation is taken care by SELK and it is also the substrate of calpains, which are proteases involved in modulating apoptosis.
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