SEC16 homolog A (SEC16A) is a 250kDa protein involved in the membrane trafficking from the endoplasmic reticulum. It localizes to concave cup-shaped structure in the endoplasmic reticulum.
Synonyms: Anti-CCDC88C; Anti-KIAA0310; Anti-Uncharacterized protein KIAA0310
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SEC16 homolog A (SEC16A) is associated with endoplasmic reticulum exit sites (ERES) throughout mitosis and provides a template for the rapid assembly of functional export domains in anaphase. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. SEC16A interacts physically with the COPII subunits Sec23 and Sec13, thus acting in directing the assembly of COPII on the transitional ER membrane before vesicle formation.
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